Effexor Doubles Risk of Miscarriage in Pregnant Women

Adding to the growing list of worries associated with antidepressants, a new study has found that the risk of miscarriage is significantly higher in women who take SSRI (selective serotonin reuptake inhibitor) and SNRI (serotonin-nonrepinephrine reuptake inhibitor) antidepressants, such as Effexor, early in their pregnancies.

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According to a May 31, 2010 study published online in the Canadian Medical Association Journal by scientists at the University of Montreal, women who take antidepressants like Effexor, Lexapro, Celexa, Prozac and Zoloft during the first trimester of their pregnancy were significantly more likely to miscarry than women who did not take antidepressants. Researchers found that the risk associated with miscarriage was 68 percent higher in women who used the drugs. The researchers also found that Effexor was among the antidepressants which carried the highest risk.

Researchers took data from the Quebec Pregnancy Registry. They studied pregnancies since 1997 and compared women who miscarried in their 20th week with women who did not lose their babies early in the pregnancy. The results showed that the risk of miscarriage nearly doubled with the use of venlaxafine (Effexor). The data has led researchers to warn that the use of antidepressants, especially venlaxafine, should be used with extreme caution during pregnancy.

The miscarriages may be related to malformations of essential organs. Effexor birth defect attorney, Nicole Maldonado, represents many families whose children were born with birth defects to mother’s who took Effexor, venlafaxine or Pristiq during their pregnancies. Her clients’ birth defects range from heart defects, lung defects, craniosynostosis (abnormally shaped skull), infant omphalocele (abdominal wall defects), club foot, and cleft lip and cleft palate.

According to Ms. Maldonado, whose law firm, Baum, Hedlund, Aristei & Goldman, has represented more clients in antidepressant injury cases than any other law firm in the United States, said that, “Women who take antidepressants like Effexor while pregnant are unknowingly putting their unborn babies at risk. Instead of experiencing the normal joys of child rearing, my clients are trying to save their babies lives.”

Venlafaxine has also been shown to increase the risk of developmental delays in babies.

Antidepressants such as Effexor and Pristiq may cause birth defects in newborns. According to information which has been emerging since 2005, data from various international studies show that some antidepressants may cause birth defects. The FDA has issued warnings about SSRI antidepressants since 2005, and their capability of causing birth defects.

Comments Closed


  1. Marie says:

    I am a 38 yr old mother of 3. I had a tubaligation back in 2003. On 10/6/10 I started bleeding and assumed it was my period. Later that day it became heavy and started clotting. On 10/7/10 I got up and showered for work. As I stepped out of shower felt funny and sat on toilet and splash. I took the clot out and noticed there was something small and white. I then knew I miscarried and didn’t even realize I was pregnant. I an guessing about ag wks or so. I take 40 mg of Lisinopril for bloodpressure and 10 mg of Lexapro for depression/anxiety. I now realize that most likely Lexapro contributed to the miscarriage. I’m sure my age and stress level didn’t help. Now I am horrified that since I got pregnant 7 yrs after tubal I will again. I have been in a daze. Still seeing what I saw really hurts. Memories are great but suck when they are bad ones. Please be careful everyone.

  2. j says:

    This study makes me sad, why wasn’t I told the antidepressant I am on can cause miscarriages by my doctor? This explains why I have had four unexplained miscarriages in the last 12 months!!
    I wish I had found this sooner it could have saved a lot of heartbreak…

  3. JC says:

    I actually took the lowest dose of effexor which was 37.5mg during my pregnancy. I also have hypothyroidism too. I was so scared that taking these two medications would make me lose my baby girl. Exactly 8 1/2months later via c-section I gave birth to a beautiful little girl. 8lbs 2oz 19in long. So with this study I am confused because I am trying to have more chidren. Being disabled I have to come off several different medicaions. I am not sure if I will take effexor again during my next pregnancy If I am able to become pregnant.

    thank you for your time